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About virus mentha
virus mentha archives evidence about viral interactions collected from different sources and presents these data in a complete and comprehensive way. Its data comes from manually curated protein-protein interaction databases that have adhered to the IMEx consortium. virus mentha is a resource that offers a series of tools to analyse selected proteins in the context of a network of interactions. Protein interaction databases archive protein-protein interaction (PPI) information from published articles. However, no database alone has sufficient literature coverage to offer a complete resource to investigate "the interactome".
virus mentha's approach generates every week a consistent interactome (graph). Most importantly, the procedure assigns to each interaction a reliability score that takes into account all the supporting evidence. virus mentha offers direct access to viral families such as: Orthomyxoviridae, Orthoretrovirinae and Herpesviridae plus, it offers the unique possibility of searching by host organism. The website and the graphical application are designed to make the data stored in virus mentha accessible and analysable to all users.
Go to User guide

Our service displays content extracted from different sources. This content is responsibility of the entity that makes it available.

Please, in any article making use of the data extracted from VirusMentha, refer to:

      VirusMentha: a new resource for virus-host protein interactions
      Alberto Calderone, Luana Licata, Gianni Cesareni
      Nucleic Acids Res. 2014.       doi:10.1093/nar/gku830

Data Integration Strategy and Data Source

      mentha: a resource for browsing integrated protein-interaction networks
      Alberto Calderone, Luisa Castagnoli, Gianni Cesareni
      Nature Methods 10, 690 (2013).       doi:10.1038/nmeth.2561

Source databases
Protocol used

Source databases
mentha integrates these databases because of their characteristics.
They all use the same curation policies and the same complex expansion model.

  • Oncodiet project of the Italian Ministry of Education.
  • Italian Association for Cancer Research.

User guide

How to search
The search field in the home page can be used to search gene names, UniProt IDs or keywords. In the home page you can also find a drop-down menu to select a model organism to narrow down your search.

Search overview

  • You can select an organism from the drop down menu

  • Search field to type your query:
  • Gene names such as: PTPN1, AKT1 and so on.
  • Uniprot IDs are identifiers as per UniProt: Q16825
  • Keywords can be any word like: phosphatase, kinase and so on

Search example

Search all elongation factors in arabidopsis thaliana
  • Select arabidopsis thaliana in organisms
  • Type: elongation factor
  • Click "search"

  • Type: elongation factor arabidopsis thaliana
  • Click "search"

Result page
By clicking search you will be presented with possible results.

  • You can collect proteins in the "Protein bag" by clicking “Add” or “Remove”.

  • Protein can be remove from the "Protein bag" just by clicking them in the bag.
  • Once you have added some proteins you can search again and continue adding.

  • "List" will list all binary interactions in tabular format.
  • "Preview" shows direct interaction, if any, among the collected proteins.
  • "Browse" starts the interactive Interactome Browser.

List page
The list page shows binary interaction with several details.

  • Protein A and Protein B
  • Organisms
  • Top 5 interactors in interactive graph
  • Number of evidence, reliability score, interaction type (If any evidence to be enzymatic is available).
  • Gene ontology terms highlighted in three colors by category: cellular compartment (yellow), molecular function(red) and biological process (blue).
  • Clicking "Show evidence", the full list of scientific manuscripts is reported, with links to papers.

University of Tor Vergata, Rome - Italy